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The speed[1][1]–[3][2], expense[1][1]–[4][3] and throughput[2][4] of genomic sequencing impose limitations on its use for time-sensitive acute cases, such as rare[4][3],[5][5] or antibiotic resistant infections[6][6], and large-scale testing that is necessary for containing COVID-19 outbreaks using source-tracing[7][7]–[9][8]. The major bottleneck for increasing the bandwidth and decreasing operating costs of next-generation sequencers (NGS) is the flow cell that supplies reagents for the biochemical processes; this subsystem has not significantly improved since 2005[10][9]–[12][10]. Here we report a new method for sourcing reagents based on surface coating technology (SCT): the DNA adhered onto the biochip is directly contacted by a reagent-coated polymeric strip. Compared with flow cells the reagent layers are an order of magnitude thinner while both the reagent exchange rate and biochip area are orders of magnitude greater. These improvements drop the turn-around time from days to twelve hours and the cost…