.NET Standard 2.1 из под .NET Framework не таргетится вроде бы
Given many of the API additions in .NET Standard 2.1 require runtime changes in order to be meaningful, .NET Framework 4.8 will remain on .NET Standard 2.0 rather than implement .NET Standard 2.1. .NET Core 3.0 as well as upcoming versions of Xamarin, Mono, and Unity will be updated to implement .NET Standard 2.1.