Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference …

LinkОсновы лекарственной химии куркумина, 2017 г.Сгенерированная сводка:Куркумин входит в состав средства традиционной медицины, известного как куркума.Вероятная ложная активность куркумина in vitro и in vivo привела к более чем 120 клиническим испытаниям куркуминоидов против нескольких заболеваний.Ни одно двойное слепое плацебо-контролируемое клиническое испытание куркумина не было успешным.Abstract:Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential…

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