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Amyotrophic lateral sclerosis is a fast progressing and lethal neurodegenerative disease that predominantly affects the upper and lower motor neurons. To this point, there is no cure for this pathology and patients have a life expectancy of 3 months to 5 years. Only 10% of cases are due to genetic and hereditary reasons (familial ALS), leaving 90% of patients in the dark of the underlying mechanism of their pathology (sporadic ALS). Only two FDA approved compounds, Riluzole, which prolongs life for up to 3 months, and Edaravone, which was shown to slow down disease progression, are used to treat ALS patients, however, they remain drugs of low efficiency. Out of this reason, researchers worldwide are establishing models and using state-of-the-art technology to investigate this disease. Although our community of ALS scientists and clinicians is eager to beat this pathology, we face many obstacles in the form of patient heterogeneity, different molecular phenotypes, and technical limitations. To overcome these burdens, I believe we need to change our mindset and perspective on this disease and step one step back to discover novel niches of research. Patient cohorts, genetics, iPSCs, stem cell therapy, vitamin supplements - what do we actually know about this disease and how can we pave a new path for effective treatment?
Full details: check genomics.org.ua or the Facebook event page.VV
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